If you already have a Windows system, you could skip running Windows software on your Mac completely and use remote desktop software to access the Windows machine from your Mac’s desktop. Organizations with business software that runs on Windows can host Windows servers and make their applications available to Macs, Chromebooks, Linux PCs, iPads, Android tablet, and other devices. If you’re just a home user who also has a Windows PC, you could configure that Windows PC for remote access and connect to it whenever you need a Windows application. Bear in mind that this isn’t ideal for visually intensive applications like PC games.
If you’re a Chrome user, you can even use Chrome Remote Desktop to connect to a Windows PC running Chrome from your Mac running Chrome.
All these tricks obviously require more work than simply installing a Windows program on a Windows PC. If you have a Mac, you should focus on using Mac software when possible. Windows programs won’t be as integrated or work as well.
You may have to buy a Windows license for your Mac to get the best compatibility, whether you’re using a virtual machine or installing Windows in Boot Camp. Wine and CrossOver are nice ideas, but they aren’t perfect.